abstract：:Previous work has shown that morphine suppresses the pulmonary immune response to infection and reduces pulmonary inflammation. No published studies have addressed the impact of morphine on lymphocyte function in the lungs without infection. This study addressed this question by assessing the impact of acute morphine ...

journal_title：International immunopharmacology

authors： Coussons-Read ME,Giese S

更新日期：2001-08-01 00:00:00

abstract：:We have observed that CD4+ T cell counts in human immunodeficiency virus (HIV)-1-infected patients treated with only Korean red ginseng (KRG) are maintained or even increased for a prolonged period. In the present study, we investigated whether the development of resistance mutations in reverse transcriptase (RT) to z...

journal_title：International immunopharmacology

authors： Cho YK,Sung H,Lee HJ,Joo CH,Cho GJ

更新日期：2001-07-01 00:00:00

abstract：:Increased progesterone sensitivity of pregnancy lymphocytes is due to activation-induced appearance of progesterone binding sites in the lymphocytes. Following recognition of fetally derived antigens gamma/delta TCR+ cells develop progesterone receptors. Progesterone binding results in the synthesis of a mediator prot...

journal_title：International immunopharmacology

authors： Szekeres-Bartho J,Barakonyi A,Par G,Polgar B,Palkovics T,Szereday L

更新日期：2001-06-01 00:00:00

abstract：:GSTM has been used for long in the treatment of rheumatoid arthritis (RA). However, its mechanism of action is still poorly understood. In the last decade, tumor necrosis factor-alpha (TNF-alpha) has emerged as the major pro-inflammatory cytokine in the pathogenesis of RA. We studied the effect of GSTM on spontaneous ...

journal_title：International immunopharmacology

authors： Mangalam AK,Aggarwal A,Naik S

更新日期：2001-06-01 00:00:00

abstract：:Here, we report the immunomodulating potential of N-palmitoyl-amino-ethyl-rigin amide (PR) and N-cholestanyl-amino-ethyl-rigin amide (CR), the two new structural analogs of rigin (an IgG-derived tetrapeptide). Their activity profiles are compared with native tuftsin (NT) and/or N-palmitoyl-amino-ethyl-tuftsin amide (P...

journal_title：International immunopharmacology

authors： Dutta RC,Puri A,Anand N

更新日期：2001-05-01 00:00:00

abstract：:Bradykinin B1 and B2 receptors, members of the G-protein coupled receptor superfamily, are involved in inflammation and pain. Chinese hamster ovary (CHO) cells stably expressing the human B2 bradykinin receptor (CHO-B2) were used to characterize the signal transduction pathways associated with this receptor and its re...

journal_title：International immunopharmacology

authors： Zhang SP,Wang HY,Lovenberg TW,Codd EE

更新日期：2001-05-01 00:00:00

abstract：:Mannan-binding lectin (MBL) constitutes an important part of the innate immune defence by effecting the deposition of complement on microbial surfaces. MBL deficiency is among the most common primary immunodeficiencies and is associated with recurrent infections and symptoms of poor immune complex clearance. Plasma-de...

journal_title：International immunopharmacology

authors： Vorup-Jensen T,Sørensen ES,Jensen UB,Schwaeble W,Kawasaki T,Ma Y,Uemura K,Wakamiya N,Suzuki Y,Jensen TG,Takahashi K,Ezekowitz RA,Thiel S,Jensenius JC

更新日期：2001-04-01 00:00:00

abstract：:High amounts of nitric oxide (NO) production following the induction of inducible NO synthase (iNOS) gene expression has been implicated in the pathogenesis of inflammatory diseases. Capsaicin, a vanilloid receptor agonist, is known to have an inhibitory effect on NO production in macrophages. In the present study, we...

journal_title：International immunopharmacology

authors： Oh GS,Pae HO,Seo WG,Kim NY,Pyun KH,Kim IK,Shin M,Chung HT

更新日期：2001-04-01 00:00:00

abstract：:Factor H is a 150 kDa single chain plasma glycoprotein that plays a pivotal role in the regulation of the alternative pathway of complement. Primary sequence analysis reveals a structural organization of this plasma protein, in 20 homologous units, called Short Consensus Repeats (SCRs), each about 60 amino acids long....

journal_title：International immunopharmacology

authors： Zipfel PF,Skerka C,Caprioli J,Manuelian T,Neumann HH,Noris M,Remuzzi G

更新日期：2001-03-01 00:00:00

abstract：:The opioid peptide methionine-enkephalin (MENK) has significant immunomodulatory ability in addition to its neurotransmitter function. Since neutral endopeptidase (NEP, CD10, enkephalinase EC 3.4.24.11) cleaves opioid peptides, the presence and activity of NEP in neutrophils from different persons might be responsible...

journal_title：International immunopharmacology

authors： Balog T,Marotti T,Abramić M,Beusan-Svoboda I,Sobocanec S,Hrsak I

更新日期：2001-03-01 00:00:00

abstract：:P-glycoprotein (PGP), an ATP-dependent membrane transporter is found in epithelial tissues of the liver, kidneys, intestine and blood-brain barrier. In tumor cells, PGP is often overexpressed and confers multidrug resistance toward cancer chemotherapeutics. It has been previously shown in rats that induction of an inf...

journal_title：International immunopharmacology

authors： Hartmann G,Kim H,Piquette-Miller M

更新日期：2001-02-01 00:00:00

abstract：:Human melanoma Colo 679 cells were made resistant to doxorubicin (adriamycin, ADM) by continuous exposure to ascending concentrations of the drug and Colo/ADM80; a variant which grew continuously in the presence of 80 ng/ml of ADM was thus established. Human peripheral blood mononuclear cells (PBMC) produced interfero...

journal_title：International immunopharmacology

authors： Micallef MJ,Darmanin S,Buhagiar JA,Camilleri-Podesta MT,Yamauchi H,Kurimoto M,Inglott AS,Ellul-Micallef R

更新日期：2001-02-01 00:00:00

abstract：:Kappa opioid agonists alter some immune functions of macrophages, and T- and B-lymphocytes. The mouse thymoma cell lines R1.G1 and R1EGO express only kappa-opioid receptors and these kappa-opioid receptors are coupled to an inhibitory GTP-binding regulatory protein. Binding of kappa-opioid agonists to the opioid recep...

journal_title：International immunopharmacology

authors： Martin-Kleiner I,Bidlack JM

更新日期：2001-01-01 00:00:00

abstract：:Interleukin-10 is a potent suppressive factor that down-regulates cellular immune response via inhibition of the production of TH1 cytokines. Histamine shifts the TH1/TH2 balance from TH1 to TH2 cytokines making the effects of histamine on IL-10 secretion an important factor in this switch. This study was designed to ...

journal_title：International immunopharmacology

authors： Osna N,Elliott K,Khan MM

更新日期：2001-01-01 00:00:00